![]() ![]() Finally, the issue of pesticide usage on cannabis crops is addressed. This overview covers a wide range of cannabis topics, initially examining issues in dispensaries and self-administration, plus regulatory requirements for production of cannabis-based medicines, particularly the Food and Drug Administration “ Botanical Guidance.” The remainder pertains to various cannabis controversies that certainly require closer examination if the scientific, consumer, and governmental stakeholders are ever to reach consensus on safety issues, specifically: whether botanical cannabis displays herbal synergy of its components, pharmacokinetics of cannabis and dose titration, whether cannabis medicines produce cyclo-oxygenase inhibition, cannabis-drug interactions, and cytochrome P450 issues, whether cannabis randomized clinical trials are properly blinded, combatting the placebo effect in those trials via new approaches, the drug abuse liability (DAL) of cannabis-based medicines and their regulatory scheduling, their effects on cognitive function and psychiatric sequelae, immunological effects, cannabis and driving safety, youth usage, issues related to cannabis smoking and vaporization, cannabis concentrates and vape-pens, and laboratory analysis for contamination with bacteria and heavy metals. Cannabis Contaminants: Heavy Metals, Microbes and Recent Data on Pesticides.Cannabis Concentrates: “Dabs, Wax, and Shatter”.Smoking and Vaporizers (Adapted and Updated from Russo And Hohmann, 2013).Cognitive Issues and Neuropsychiatric Sequelae.Cannabis, Drug Abuse Liability, and DEA Scheduling.Blinding, Placebo, and Design Issues in Cannabis Randomized Clinical Trials.Anti-Inflammatory Drugs and Cyclo-Oxygenase (COX) Inhibition.Pharmacokinetics and Cannabinoid Dose Titration.Can a Botanical Agent Become a Prescription Medicine?.Controversies in Cannabis Dispensaries, Coffee Shops, and Self-Administration.The editor and reviewer's affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. ![]()
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